COMBINING THE CLASSIFICATION AND PHARMACOPHORE APPROACHES TO UNDERSTAND HOMOGENEOUS OLFACTORY PERCEPTIONS AT PERIPHERAL LEVEL: FOCUS ON TWO AROMA MIXTURES

The mechanisms involved in the homogeneous perception of odorant mixtures remain largely unknown.With the aim of enhancing knowledge about blending and masking mixture perceptions, we focused on structure-odor relationships by combining the classification and pharmacophore approaches.We built a dataset of about 5000 molecules and their related odor

Epithelial tissues form folded structures during embryonic development and organogenesis.Whereas substantial efforts have been devoted to identifying mechanical and biochemical mechanisms that Discontinued induce folding, whether and how their interplay synergistically shapes epithelial folds remains poorly understood.Here we propose a mechano-bioc

Eukaryotes have linear chromosomes with domains called telomeres at both ends.The telomere DNA consists of a simple tandem repeat sequence, and multiple telomere-binding proteins including the shelterin complex maintain chromosome-end structures and regulate various biological reactions, such as protection of chromosome ends and control of telomere

Abstract Background The Taiwan government adopted National Health Insurance (NHI) in 1995, providing universal health care to all citizens.It was financed by mandatory premium contributions made by employers, employees, and the government.Since then, the government has faced increasing challenges to control NHI expenditures.The aim of this study wa

ABSTRACT Objective To retrospectively evaluate the Rolling outcomes of patients with low and intermediate risk thyroid carcinoma treated with total thyroidectomy (TT) and who did not undergo radioiodine remnant ablation (RRA) and to compare them to patients receiving low dose of iodine (30 mCi).Subjects and methods A total of 189 differentiated thy